When choosing materials and lens care, careful consideration should be given to wearing patterns, environmental conditions and above all, compliance. As most ECPs recommend multi-purpose solutions now, it is vital that these lens care products can be efficacious and also enhance the wearing experience for the contact lens wearer.
Biotrue® Multi-Purpose Solution has a dual-disinfecting system using polyaminopropyl biguanide (PHMB) and polyquaternium (PQ-1). This combination provides efficacy against bacteria, fungi, and Acanthamoeba^1-2^. However the specific pH value of Biotrue® MPS optimises the environment for these disinfectants meaning that not only do the log kill reductions for bacteria and fungi exceed the requirements for FDA/ISO stand-alone testing^2^ (see figure 1 and 2), but also the concentrations of these preservatives are extremely low (see figure 3).
For extra comfort, at 7.5, the pH of Biotrue® MPS is designed to match the range of healthy tears (7.3-7.7)^3^ to help avoid any stinging reaction on lens application.
Tears contain high concentrations of proteins, which have natural antibacterial properties. An example is lysozyme; in its active state, is directly toxic to bacteria (lysozyme hydrolyses the cell walls of bacteria)^4^.
Biotrue® MPS contains an ingredient called sulfobetaine; a zwitterion, which surrounds and aids to protect active lysozyme, so it remains in the native state and retains its inherent activity^5^. In fact, a study demonstrated 90.1% of lysozyme was stabilised in its active form with Biotrue® MPS^6^. Not all tear proteins are this useful. As they denature, proteins need to be eliminated to prevent deposition. Biotrue® MPS lifts and dissolves only denatured proteins, preventing them from building up as deposits on the contact lens surface.
Biotrue® MPS contains hyaluronan (HA). This hydrophilic glycosaminoglycan provides a moisture-rich hydrating network remaining on both hydrogel and silicone hydrogel lenses for up to 20 hours^7^ to keep lenses cushioned and hydrated for all day comfort.
Biotrue® MPS is an innovative solution. It has high biocidal efficacy yet is gentle on the surface of the eye, promotes the eye’s natural ability to defend itself from microbes by protecting active tear proteins and maintaining a long lasting hydrated surface on the contact lens.
A solution for modern day reusable contact lenses.
Author: Serena Kalsi, FBDO CL, Professional Relations Consultant - Bausch + Lomb UK
* Outside of the USA, RevitaLens OcuTec is marked as Complete RevitaLens.
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